Phenotypic heterogeneity and tumor immune microenvironment directed therapeutic strategies in pancreatic ductal adenocarcinoma
Pancreatic cancer is an aggressive tumor with high metastatic potential which leads to decreased survival rate and resistance to chemotherapy and immunotherapy.Nearly 90% of pancreatic cancer comprises pancreatic ductal adenocarcinoma (PDAC).About 80% of diagnoses takes place at the advanced metastatic stage when it is unresectable, which renders c