PHENOTYPIC HETEROGENEITY AND TUMOR IMMUNE MICROENVIRONMENT DIRECTED THERAPEUTIC STRATEGIES IN PANCREATIC DUCTAL ADENOCARCINOMA

Phenotypic heterogeneity and tumor immune microenvironment directed therapeutic strategies in pancreatic ductal adenocarcinoma

Pancreatic cancer is an aggressive tumor with high metastatic potential which leads to decreased survival rate and resistance to chemotherapy and immunotherapy.Nearly 90% of pancreatic cancer comprises pancreatic ductal adenocarcinoma (PDAC).About 80% of diagnoses takes place at the advanced metastatic stage when it is unresectable, which renders c

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Review: Heide von Felden (Ed.) (2007). Methodendiskussion in der Biographieforschung [Methodological Issues in Biographical Research: Classical and Innovative Perspectives on Qualitative Analysis]

This article assesses the extent to which the book under review lives up to the expectations raised by its title.The focus is thus on whether the results of memo board interpreting the five featured case studies justify the methodological effort.The interaction between the text and the reader is left out and this is problematic when it comes to int

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Spinal Anesthesia for Amyotrophic Lateral Sclerosis Patient Undergoing Lower Extremity Orthopedic Surgery: An Overview of the Anesthetic Considerations

Jason K Panchamia, Carmelina Gurrieri, Adam W Amundson Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USACorrespondence: Jason K PanchamiaDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USATel +1 507-284-9698Fax + 1 507-284-0120Email Panchamia.Jason@ma

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